BDNF (Brain-Derived Neurotrophic Factor)

BDNF is a protein that acts like fertilizer for neurons — it promotes neuronal survival, growth, and synaptic plasticity. Without enough BDNF, neurons are fragile and connections between them don't form properly. In MHS: MEF2C regulates BDNF expression, so MEF2C deficiency means reduced BDNF, which compounds the neurological damage. It's like trying to build a house while simultaneously cutting the supply of building materials.